For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | FOXP3 is a key transcription factor for regulatory T cells (Tregs) and is crucial for maintaining immune tolerance and homeostasis. It is highly expressed in CD4⁺CD25⁺ regulatory T cells and regulates their development and function. FOXP3 exerts its immunosuppressive effects by binding to the promoter regions of target genes and inhibiting the production of pro-inflammatory cytokines. In mice, the absence of FOXP3 leads to severe autoimmune diseases, such as multi-organ inflammation and lymphoproliferation. Additionally, the role of FOXP3 in immune regulation makes it an important target for studying autoimmune diseases and cancer immunotherapy. Modulating FOXP3 activity or the number of Tregs expressing FOXP3 holds promise for developing therapeutic strategies for various immune-related diseases. |
Alternate Names | - |
Uniprot ID | Q99JB6 |
Clone No | - |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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