For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD49d is an important member of the integrin family. It combines with β1 or β7 subunits to form α4β1 (VLA-4) or α4β7 integrins. CD49d is primarily expressed on leukocytes, including T cells, B cells, monocytes, and dendritic cells. By binding to extracellular matrix proteins (such as fibronectin) or cell surface adhesion molecules (such as VCAM-1), CD49d plays a key role in cell adhesion, migration, and the homing of immune cells. In immune responses, CD49d-mediated cell adhesion facilitates the infiltration and activation of T cells at sites of inflammation. Additionally, CD49d is involved in regulating the homing and engraftment of hematopoietic stem cells. Due to its important roles in immune and hematopoietic processes, CD49d is a potential target for studying immune regulation and the treatment of related diseases. |
Alternate Names | VLA-4α |
Uniprot ID | P13612 |
Clone No | PS/2 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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