Anti-Mouse CD366 Antibody [RMT3-23]

Background

CD366 is a co-stimulatory molecule primarily expressed on the surface of activated CD4⁺ and CD8⁺ T cells. It provides positive co-stimulatory signals by binding to its ligand OX40L (CD252), enhancing T cell activation, proliferation, and cytokine secretion. In immune responses, the CD366 signaling pathway is crucial for maintaining T cell survival and the formation of immunological memory. Additionally, CD366 is involved in regulating the intensity of T cell-mediated immune responses and promoting the differentiation of Th1 and Th2 cells. In cancer immunotherapy research, CD366 is considered a potential therapeutic target; activating the CD366 signaling pathway can enhance antitumor immune responses and promote the infiltration and function of tumor-specific T cells.