For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD274 is a key member of the B7 family and belongs to the immunoglobulin superfamily. It is a type I transmembrane protein expressed on various immune and non-immune cells, including T cells, B cells, dendritic cells, macrophages, and certain tumor cells. CD274 transmits inhibitory signals by binding to PD-1, suppressing T cell proliferation and cytokine secretion to regulate immune responses and maintain immune tolerance. In the tumor microenvironment, high expression of CD274 is closely related to tumor immune evasion, and its blockade can enhance antitumor immunity. Additionally, CD274 is involved in regulating macrophage polarization and inhibiting inflammatory responses. Therefore, CD274 is a crucial target for cancer immunotherapy, with its inhibitors widely applied in clinical settings. |
Alternate Names | PD-L1 |
Uniprot ID | Q9EP73 |
Clone No | 10F.9G2™ |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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