Anti-Mouse IL-7 Antibody [A7R34]

Background

IL-7 is an essential hematopoietic cytokine primarily secreted by bone marrow stromal cells and thymic stromal cells, playing a crucial role in the development, proliferation, and survival of B and T cells. IL-7 activates the JAK-STAT and PI3K-Akt-mTOR signaling pathways through its receptor complex (composed of IL-7Rα and the common γ-chain receptor), promoting lymphocyte proliferation and anti-apoptotic effects. In immune responses, IL-7 enhances the function of T and B cells and promotes the generation of cytotoxic T lymphocytes (CTL), lymphokine-activated killer (LAK) cells, and natural killer (NK) cells. Additionally, IL-7 has been studied for its ability to enhance antitumor immune responses by modulating the activity and number of immune cells, thereby improving immune function. IL-7 is also investigated for its potential to augment vaccine-induced immune responses, increasing the efficacy and duration of vaccines.