Anti-Mouse CD11a Antibody [M17/4]

Background

CD11a is a key member of the integrin family, encoding the 180 kDa integrin α1 subunit that combines with the CD18 (β2 integrin subunit) to form the α1β2 integrin heterodimer. It is widely expressed on lymphocytes, granulocytes, monocytes, and macrophages, and is significantly upregulated on activated T cells. CD11a plays a critical role in the adhesion and migration of immune cells, mediating the adhesion of lymphocytes to vascular endothelial cells and participating in immune cell costimulation. Additionally, the LFA-1 formed by the combination of CD11a and CD18 regulates T cell activation by influencing the formation of the immunological synapse. In the tumor microenvironment, the expression of CD11a in tumor-associated microglia is closely related to tumor growth, and its functional inhibition can reduce tumor cell proliferation. Therefore, CD11a not only plays an important role in the activation and migration of immune cells but may also be a potential target for tumor therapy.