For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | IL-6R is a key component in IL-6 signaling, consisting of two subunits: IL-6Rα and IL-6Rβ (gp130). IL-6Rα is a type I transmembrane glycoprotein that binds IL-6 and modulates its bioactivity. IL-6Rα exists in two forms: membrane-bound (mIL-6R) and soluble (sIL-6R). sIL-6R can be released from activated CD4⁺ T cells through proteolysis, and it binds IL-6 to activate gp130, promoting cell regeneration and anti-inflammatory signaling. IL-6R plays crucial roles in immune responses, cell growth, and differentiation, as well as in acute-phase reactions and hematopoiesis. Additionally, IL-6R is implicated in the pathogenesis of various diseases, including multiple myeloma, autoimmune diseases, and prostate cancer. |
Alternate Names | - |
Uniprot ID | P22272 |
Clone No | 15A7 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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