For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | VEGFR-2 is one of the major receptors for vascular endothelial growth factor (VEGF) and is predominantly expressed on vascular endothelial cells. VEGFR-2 activates downstream signaling pathways (such as PI3K-Akt and MAPK) by binding to its ligand VEGF, playing a key role in angiogenesis, vascular repair, and maintenance of vascular integrity. During embryonic development, VEGFR-2 is essential for vascular formation and embryonic survival. In adult organisms, activation of VEGFR-2 promotes the formation of new blood vessels, which is significant for tissue repair and regeneration. Additionally, VEGFR-2 is also important in various pathological conditions (such as cancer and ischemic diseases), and its abnormal activation is closely related to tumor angiogenesis and metastasis. Therefore, VEGFR-2 is an important target for studying vascular physiology and pathology and a potential target for anti-tumor therapy and vascular repair therapy. |
Alternate Names | KDR/ Flk-1 |
Uniprot ID | P35968 |
Clone No | DC101-CP132 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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