For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | IL-1β is a potent pro-inflammatory cytokine produced and secreted by monocytes, macrophages, and dendritic cells. IL-1β is initially synthesized as an inactive precursor (pro-IL-1β) and is activated by caspase-1 within the inflammasome in response to inflammatory stimuli, including microbial products and endogenous danger signals. The mature IL-1β exerts its effects through the type I IL-1 receptor (IL-1R1), regulating inflammatory responses and participating in cell proliferation, differentiation, and apoptosis. Additionally, IL-1β plays a significant regulatory role in female reproduction. Abnormal expression of IL-1β is associated with various auto-inflammatory syndromes, such as CAPS, which is caused by mutations in the inflammasome receptor NLRP3 that lead to excessive IL-1β activation. |
Alternate Names | - |
Uniprot ID | P10749 |
Clone No | B122 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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