Anti-Mouse IL-17A Antibody [17F3]

Background

IL-17A is a critical pro-inflammatory cytokine and a member of the IL-17 cytokine family. It is produced by various immune cells, including activated Th17 cells, CD8⁺ T cells, γδT cells, natural killer T cells (NKT cells), monocytes, and neutrophils. IL-17A plays a key role in host defense mechanisms by inducing the production of antimicrobial peptides (such as defensins and S100 proteins), cytokines (such as IL-6, G-CSF, and GM-CSF), chemokines (such as CXCL1, CXCL5, and IL-8), and matrix metalloproteinases (such as MMP1, MMP3, and MMP13). Additionally, IL-17A activates NF-κB and MAPK signaling pathways through the IL-17RA and IL-17RC receptor complex, promoting inflammatory responses. In pathological conditions, IL-17A is closely associated with the development of various autoimmune diseases, such as psoriasis and ankylosing spondylitis. It also modulates the tumor microenvironment by recruiting myeloid-derived suppressor cells (MDSCs) to inhibit antitumor immunity. Therefore, IL-17A is a potential therapeutic target for autoimmune diseases and cancer.