Anti-Mouse IL-10 Antibody [1B1.3A]

Background

IL-10 is a pleiotropic cytokine with broad immunoregulatory functions. It is primarily produced by Th2 helper T cells, macrophages, and B cells. IL-10 exerts its anti-inflammatory effects by binding to its heterotetrameric receptors (IL10RA and IL10RB), activating the JAK-STAT signaling pathway, and inhibiting the production of pro-inflammatory cytokines such as TNF-α, IL-1, and IL-6. Additionally, IL-10 downregulates the expression of MHC class II molecules and co-stimulatory molecules, thereby suppressing the function of antigen-presenting cells and modulating T cell activation. In disease models, IL-10 expression is associated with various pathological processes. For example, in a mouse model of herpes simplex encephalitis, upregulation of IL-10 correlates with the severity of neuronal damage. In tumor immunology, IL-10 can modulate the tumor microenvironment by regulating the activity of immune cells. Therefore, IL-10 holds significant research and therapeutic potential in autoimmune diseases, infectious diseases, and cancer.