For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD119 is one of the subunits of the interferon-γ (IFN-γ) receptor and belongs to the cytokine receptor family. It forms a functional receptor with IFN-γ R2, mediating IFN-γ signaling. IFN-γ R1 is constitutively expressed on the surface of almost all cells, and its extracellular, transmembrane, and cytoplasmic domains all participate in signal transduction. Upon binding of IFN-γ to the receptor complex, IFN-γ R1 and IFN-γ R2 oligomerize and transphosphorylate, activating JAK1 and JAK2. Subsequently, STAT1 is recruited and phosphorylated, translocating to the nucleus to regulate the expression of IFN-responsive genes. CD119 plays a crucial role in antibacterial, antiviral, and antitumor responses, and its deficiency impairs IFN-γ-mediated immune responses, increasing susceptibility to infections. |
Alternate Names | IFN-γR1 |
Uniprot ID | P13616 |
Clone No | GR-20 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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