Anti-Mouse IFNAR-1 Antibody [MAR1-5A3]

Background

IFNAR-1 is a subunit of the type I interferon (IFN-α/β) receptor and a member of the type I IFN receptor family. It forms a heterodimeric receptor with IFNAR-2 and mediates IFN-induced signaling. IFNAR-1 interacts with tyrosine kinase 2 (Tyk2) to stabilize the receptor on the plasma membrane and initiate type I IFN-induced STAT signaling. Upon activation by IFNs, IFNAR-1 and IFNAR-2 undergo conformational changes that promote a cascade of downstream signaling events, including the phosphorylation of Tyk2 and JAK1, and the formation of the IFN-stimulated gene factor 3 (ISGF3) complex composed of phosphorylated STAT1, STAT2, and IRF9. IFNAR-1 is expressed on peripheral blood B cells and monocytes in mice, where it mediates the differentiation and activation of these cells. In mice, deficiency of IFNAR-1 increases susceptibility to bacterial and parasitic infections and accelerates tumor growth.