Anti-Mouse GM-CSF Antibody [MP1-22E9]

Background

GM-CSF is a monomeric glycoprotein and a member of the colony-stimulating factor family. It was initially defined as a hematopoietic factor that supports the in vitro colony formation of granulocyte and macrophage progenitors. GM-CSF is produced by various cell types, including activated T cells, B cells, macrophages, mast cells, endothelial cells, and fibroblasts, which secrete GM-CSF in response to cytokines and other immune and inflammatory stimuli. GM-CSF not only promotes the proliferation and differentiation of granulocyte and macrophage progenitors but also acts as a growth factor for erythroid, megakaryocytic, and eosinophilic progenitors. Additionally, GM-CSF functions as a survival factor in mature hematopoietic cells, activating the effector functions of granulocytes, monocytes/macrophages, and eosinophils. In inflammatory and immune responses, GM-CSF activates multiple signaling pathways through its receptor complex, regulating cell survival, proliferation, and functional activation.