For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD183 is a G protein-coupled, seven-transmembrane chemokine receptor that binds three ligands: CXCL9 (Mig), CXCL10 (IP-10), and CXCL11 (ITAC). It is expressed on various cell types, including activated T cells, natural killer (NK) cells, and certain subsets of B cells. CD183 plays a crucial role in immune responses, particularly in the recruitment and migration of inflammatory cells, which are prominent in Th1-mediated immune reactions. Additionally, CD183 is involved in regulating T cell responses to grafts, and CXCR3 knockout mice exhibit compromised allograft rejection responses. Given its significance in inflammation and immune responses, CD183 is considered an important target for the development of small molecule antagonists to treat various inflammatory diseases. |
Alternate Names | CXCR3 |
Uniprot ID | O88410 |
Clone No | CXCR3-173 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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