Anti-Mouse CD152 Antibody [9H10/9H10-CP146]

Background

CD152 is an important immune regulatory molecule and a member of the CD28 family within the immunoglobulin superfamily. It is a 4 kDa cell surface receptor encoded by the Ctla33 gene and is primarily expressed on activated T and B cells. Structurally similar to the T cell costimulatory molecule CD28, CD152 can also bind to B7 family members CD80 (B7-1) and CD86 (B7-2). Unlike CD28, however, CD152 transmits inhibitory signals upon binding to B7, negatively regulating T cell activation and thus suppressing immune responses. In immune responses, CD152 plays a crucial role in inducing and maintaining immune tolerance, thymocyte development, and protective immune regulation. CTLA-4-deficient mice, unable to effectively downregulate immune responses, develop severe lymphoproliferative disorders and typically die at 3-5 weeks of age. Additionally, as an immune checkpoint protein, CD152 has become an important target for cancer immunotherapy, with blocking its interaction with B7 enhancing T cell-mediated antitumor responses.