Anti-Mouse CD96 Antibody [3.3]

Background

CD96 is a type I transmembrane glycoprotein and a member of the immunoglobulin superfamily. It is expressed at low levels on resting natural killer (NK) cells and T cells, but is highly upregulated on activated NK and T cells. The primary function of CD96 is to regulate the activity of T cells and NK cells by interacting with its high-affinity ligand CD155 (also known as poliovirus receptor, PVR), promoting their ability to attack infected and tumor cells. Additionally, CD96 is involved in the negative regulation of NK cell-mediated immune surveillance. In tumor immunology, CD96 has been identified as a new target for cancer immunotherapy, with blocking antibodies shown to inhibit primary tumor growth and reduce metastasis. For instance, in mouse models of pancreatic ductal adenocarcinoma (PDAC), blocking CD96 can prevent postoperative recurrence and promote long-term survival.