Anti-Mouse CD80 Antibody [16-10A1]

Background

CD80 is a costimulatory molecule and a member of the immunoglobulin superfamily. It plays a crucial role in T cell activation and immune responses. CD80 is primarily expressed on the surface of antigen-presenting cells (APCs) and provides the costimulatory signals required for T cell activation by binding to CD28 on T cells. Additionally, CD80 can bind to CTLA-4, an inhibitory receptor on T cells, which inhibits T cell activation and regulates immune responses. In tumor immunology, the expression level of CD80 is closely related to antitumor immune responses. High levels of CD80 expression can enhance T cell-mediated antitumor reactions. Moreover, CD80 expression on skin stem cells has been found to promote the local expansion of regulatory T cells, thereby orchestrating tissue repair within an inflammatory environment.