For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD73 is a 70 kDa glycosylphosphatidylinositol (GPI)-anchored cell surface protein encoded by the NT5E gene. It is expressed in various cell types, including lymphocytes, endothelial cells, epithelial cells, fibroblasts, and glial cells. The primary function of CD73 is to hydrolyze extracellular AMP into adenosine, which plays a crucial role in immune regulation. Adenosine, by binding to adenosine receptors (such as A2AR), suppresses immune responses and promotes immune evasion. In addition, CD73 is involved in cell adhesion, interactions with the extracellular matrix, and the invasion and metastasis of tumors. In the tumor microenvironment, high expression of CD73 is associated with immune suppression, angiogenesis, and metastasis. Studies have shown that hypoxia can increase the expression of CD73 in mouse brain microvascular endothelial cells, highlighting its role in pathological conditions. |
Alternate Names | NT5E |
Uniprot ID | Q61503 |
Clone No | TY/23 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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