Anti-Mouse CD70 Antibody [FR70]

Background

CD70 is an important member of the tumor necrosis factor (TNF) family and a type II transmembrane glycoprotein. In mice, CD70 is mainly expressed on the surface of activated T cells and B cells, acting as the ligand for CD27 and participating in the CD70-CD27 signaling pathway, which is crucial for the generation and maintenance of T cell immunity. This pathway promotes T cell proliferation and cytokine secretion by activating the NF-κB and JNK signaling pathways. Additionally, CD70 has antiviral activity and regulates the viability of tumor cells and regulatory T cells. In tumor immunology, CD70 is highly expressed in various tumor cells and may induce immune evasion by binding to CD27. Studies have shown that blocking the CD70-CD27 pathway can enhance antitumor immune responses. Therefore, CD70 holds significant potential for application in tumor immunotherapy.