Anti-Mouse CD47 Antibody [MIAP301/MIAP410]

Background

CD47 is a widely expressed glycoprotein on the cell surface and is present in various cell types in mice. It plays a crucial role in multiple physiological processes, including immune regulation, cell adhesion, and intercellular signaling. In the immune system, CD47 interacts with signal regulatory protein alpha (SIRPα) to form a “don’t eat me” signal, which helps normal cells avoid phagocytosis by macrophages and maintains immune homeostasis. Additionally, CD47 is involved in regulating angiogenesis and cell migration. In recent years, its role in tumor immunity has attracted attention, as its abnormal expression on tumor cells is closely related to immune evasion. Studying CD47 can help to better understand immune regulation mechanisms and provide new ideas for tumor therapy.