Anti-Mouse CD45RB Antibody [MB23G2(HB220)]

Background

CD45RB is a splice variant of the CD45 protein, belonging to the receptor-type tyrosine phosphatase family. It is predominantly expressed on peripheral B cells, cytotoxic T cells, subsets of helper T cells, thymocytes, and at low levels on macrophages and dendritic cells. CD45RB plays a critical role in lymphocyte development and antigen signaling by modulating the activity of Src family kinases, thereby influencing cell survival and apoptosis. The expression of CD45RB varies among different cell types and is dependent on the cell's physiological state. In the immune system, CD45RB is involved in the regulation of immune responses by modulating signaling in T cells and B cells. Additionally, CD45RB is often used as a marker to distinguish between different subsets of T cells, particularly in studies of T cell differentiation and immune tolerance.