For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD40 is a 48 kDa type I transmembrane protein and a member of the tumor necrosis factor receptor superfamily, expressed on B cells, dendritic cells, and monocytes. It interacts with CD40L to activate signaling pathways like NF-κB, MAPK, and JAK-STAT, regulating cell proliferation, differentiation, and immune responses. In B cells, CD40 activation supports survival, Ig class switching, and memory cell formation. In dendritic cells, it enhances antigen presentation and co-stimulatory molecule expression, promoting T cell activation. CD40 is also found in non-immune cells and some tumor cells, where its activation can induce macrophage activation and enhance antitumor effects. Thus, CD40 is a key target for immunotherapy. |
Alternate Names | Bp50 |
Uniprot ID | P27548 |
Clone No | FGK4.5/FGK45 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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