For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD317 is a type II transmembrane glycoprotein with a molecular mass of approximately 29-33 kDa. Initially identified as a surface marker for terminally differentiated B cells, it was later recognized as an interferon-induced antiviral factor. CD317 is expressed in various cell types, including plasmacytoid dendritic cells (pDCs), B cells, and fibroblasts. It restricts viral spread by tethering viral particles and is involved in antiviral immunity. Additionally, CD317 plays roles in tumorigenesis, exosome release, and immune regulation. In tumor models, targeting CD317 with monoclonal antibodies or shRNA can inhibit tumor growth. In mice, CD317 serves as a marker for plasmacytoid dendritic cells, aiding in their identification. |
Alternate Names | BST2/ Tetherin/PDCA-1/HM1.24 |
Uniprot ID | P23953 |
Clone No | 927 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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