Anti-Mouse CD28 Antibody [37.51]

Background

CD28 is a cell surface glycoprotein receptor predominantly expressed on activated T cells and belongs to the immunoglobulin superfamily. As the first identified costimulatory receptor, CD28 provides a critical “second signal” that enhances T cell activation, proliferation, and cytokine production. Its ligands, CD80 (B7-1) and CD86 (B7-2), are mainly found on antigen-presenting cells (APCs) and interact with CD28 to promote full T cell activation. Additionally, CD28 is involved in regulating T cell immune tolerance, and modulating its signaling pathway can prevent autoimmune diseases and transplant rejection. In mice, CD28 superagonist antibodies can promote the expansion of regulatory T cells (Tregs) without affecting effector T cells (Teff), offering potential applications in autoimmune and cancer immunotherapy.