For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD278 is an inducible costimulatory molecule belonging to the CD28 family. It is a homodimeric protein expressed on the surface of activated T cells and some thymocytes. Similar to CD28 and CTLA-4, CD278 enhances T cell activation and proliferation by binding to its ligand ICOSL, and promotes the secretion of cytokines such as IL-4, IL-10, and IL-21. Additionally, CD278 plays a crucial role in the differentiation and function of T follicular helper cells (Tfh), which are essential for high-affinity antibody production by B cells during germinal center reactions. CD278 is also involved in the stability of regulatory T cells (Treg), and disruption of its signaling can lead to immune dysregulation and autoimmune diseases. In the immune system, CD278 is an important regulator of adaptive immune responses, providing protection against autoimmune reactions. |
Alternate Names | ICOS/H4 |
Uniprot ID | Q9WVS0 |
Clone No | C398.4A |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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