For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD276 is an immune regulatory molecule belonging to the B7 family and is a type I transmembrane protein. It is expressed in various immune cells, such as antigen-presenting cells and T cells, and has both costimulatory and coinhibitory functions. In mice, CD276 is constitutively expressed on professional antigen-presenting cells (APCs) and is upregulated upon lipopolysaccharide (LPS) activation. Its functions are complex; it can inhibit natural killer (NK) cell-mediated cytotoxicity while also enhancing the induction of cytotoxic T cells and selectively stimulating IFN-γ production. Additionally, CD276 is highly expressed in various tumors, where it is associated with tumor progression, invasion, and metastasis, making it a potential target for immunotherapy. |
Alternate Names | B7-H3 |
Uniprot ID | Q8VE98 |
Clone No | MJ18 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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