For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD275L is a member of the B7 family of costimulatory molecules. It is primarily expressed on antigen-presenting cells (APCs), such as dendritic cells, macrophages, and B cells. By binding to ICOS on T cells, CD275L provides costimulatory signals that promote T cell activation, proliferation, and cytokine production. CD275L plays a crucial role in immune responses, particularly in the differentiation of Th1 and Th2 cells, and is essential for maintaining immune balance. Additionally, it is involved in regulating immune tolerance and the development of autoimmune diseases. In cancer immunotherapy, the CD275L/ICOS signaling pathway is emerging as a potential target for immune regulation. |
Alternate Names | B7-H2 / ICOS |
Uniprot ID | Q9JHJ8 |
Clone No | HK5.3 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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