For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD272 is a coinhibitory receptor of the immunoglobulin superfamily with structural similarity to PD-1. It is expressed on T cells, B cells, bone marrow cells, splenic macrophages, and bone marrow-derived dendritic cells. BTLA interacts with its ligand HVEM (herpesvirus entry mediator, also known as TNFRSF14) to transmit inhibitory signals that negatively regulate immune responses. This inhibition is mediated through interactions with tyrosine phosphatases PTPN6 (SHP-1) and PTPN11 (SHP-2). BTLA plays a crucial role in maintaining immune tolerance and preventing autoimmune reactions, with its dysfunction linked to autoimmune diseases. Additionally, BTLA has potential regulatory functions in tumor immunity and may serve as a target for cancer immunotherapy. |
Alternate Names | BTLA |
Uniprot ID | Q7TSA3 |
Clone No | 6A6 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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