For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD254 is a member of the tumor necrosis factor superfamily and a type II transmembrane protein. It plays crucial roles in both the immune and skeletal systems. In the immune system, CD254 interacts with RANK to promote dendritic cell maturation and T cell activation. Additionally, CD254 is a key regulator of osteoclast differentiation and function, and its interaction with RANK induces osteoclast formation and bone resorption. In mice, CD254 is predominantly expressed by T cells, and its deficiency leads to a lack of osteoclasts and increased bone mass. Moreover, CD254 is involved in the regulation of interactions between immune cells, such as T cells, B cells, and dendritic cells. Therefore, CD254 has important physiological functions in immune regulation and bone metabolism. |
Alternate Names | RANKL/OPGL |
Uniprot ID | O14788 |
Clone No | IK22/5 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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