For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD209b is a C-type lectin receptor and a type II transmembrane protein, identified as the murine homolog of human DC-SIGN. It is predominantly expressed in marginal zone macrophages of the spleen and medullary macrophages of lymph nodes. CD209b recognizes and binds to pathogen-associated molecular patterns (PAMPs), such as the polysaccharide capsule of Streptococcus pneumoniae and lipopolysaccharides (LPS), and activates the complement system by binding to C1q, facilitating pathogen clearance. Additionally, CD209b is involved in the metabolism of complement component C3, and its deficiency leads to impaired C3 catabolism. As a key player in pathogen recognition and immune regulation, CD209b has become an important target for studying infectious diseases and immune response mechanisms. |
Alternate Names | DC-SIGNR1/SIGN-R1 |
Uniprot ID | Q8CJ91 |
Clone No | 22D1 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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