Anti-Mouse CD200 Antibody [OX-90]

Background

CD200 is an immunomodulatory molecule belonging to the immunoglobulin superfamily, expressed on immune and neuronal cells. It interacts with CD200R to transmit inhibitory signals, regulating the activation and function of immune cells, particularly exerting negative regulation on T and B cells to suppress excessive immune responses. In autoimmune diseases such as multiple sclerosis and systemic lupus erythematosus, reduced CD200 expression is associated with disease progression. Additionally, CD200 plays a role in tumor immune evasion, where its high expression helps tumor cells inhibit anti-tumor immune responses and promote tumor growth. In mouse models, the CD200/CD200R interaction regulates inflammatory responses and maintains immune tolerance. Therefore, the CD200/CD200R signaling pathway is a potential target for immunotherapy.