For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD19 is a B cell surface antigen belonging to the immunoglobulin superfamily, expressed on all B cell lineages except plasma cells and follicular dendritic cells (FDC). It acts as a crucial co-receptor of the B cell receptor (BCR) complex, lowering the signaling threshold for BCR activation and regulating B cell activation, proliferation, and differentiation. CD19 forms a signaling complex with molecules such as CD21 and CD81, enhancing B cell antigen recognition and antibody production. In mouse models, CD19 deficiency results in abnormal B cell development and impaired antibody generation. Additionally, CD19 is a significant target in cancer immunotherapy, especially in CAR-T cell therapies targeting B cell malignancies. |
Alternate Names | B4 |
Uniprot ID | P25918 |
Clone No | 1D3 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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