For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD137L is a ligand of the tumor necrosis factor superfamily, predominantly expressed on antigen-presenting cells (APCs) such as dendritic cells, macrophages, and B cells. It binds to CD137 (4-1BB) to provide co-stimulatory signals for T cells, enhancing their proliferation, survival, and cytokine production. In mice, CD137L plays a significant role in regulating immune responses and promoting T cell-mediated immunity. Additionally, CD137L is crucial in the tumor microenvironment, where it activates T cells and enhances the cytotoxic functions of immune cells to inhibit tumor growth. In models of atherosclerosis, CD137L signaling regulates the calcification of vascular smooth muscle cells through autophagy. Therefore, CD137L is an important target for studying immune regulation, tumor therapy, and cardiovascular diseases. |
Alternate Names | 4-1BBL/TNFSF9 |
Uniprot ID | P41274 |
Clone No | TKS-1-CP039 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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