For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Background | CD106 is a 100-110 kDa type I transmembrane glycoprotein belonging to the immunoglobulin superfamily. It contains seven C2-type immunoglobulin-like domains and is predominantly expressed on inflamed vascular endothelial cells, as well as on macrophages and dendritic cells. CD106 plays a crucial role in leukocyte-endothelial cell adhesion and signal transduction by interacting with integrin α4β1 (VLA-4) and integrin α4β7, mediating leukocyte adhesion and migration. Additionally, CD106 is involved in the regulation of osteoclastogenesis, adhesion of sickle cells under hypoxic conditions, and leukocyte recruitment to sites of inflammation. In mice, CD106 expression and function are similar to those in humans, making it an important target for studying inflammation and immune responses. |
Alternate Names | VCAM-1 |
Uniprot ID | Q3UPN1 |
Clone No | M/K-2.7 |
Host | Rat |
Reactivity | Mouse |
Isotype control | / |
Application | Flow cytometry |
Conjugation | FITC, PE, APC, PE-Cy7, APC-Cy7, PerCP |
Conjugation Information | 488/785，488/578，650/660，488/785，650/785，488/677 |
Storage Buffer | Phosphate buffered solution, pH 7.2, containing 0.09% sodium azide and 1% BSA. |
Storage | 2~8℃, Samples were stored at -20 °C for a long time to avoid repeated freezing and thawing. |
Expiration date | 24M |
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