Anti-Mouse CD137（4-1BB） Antibody [3H3]

Background

CD137 is a member of the tumor necrosis factor receptor superfamily and a type I transmembrane protein, predominantly expressed on the surface of activated CD4⁺ and CD8⁺ T cells. It provides co-stimulatory signals to T cells by binding to CD137 ligand (CD137L), enhancing T cell proliferation, survival, and cytokine production. In mice, CD137 plays a crucial role in immune responses, especially in maintaining immune reactions, resisting cell apoptosis, and enhancing immune memory. Additionally, CD137 stimulates NK cell proliferation and IFN-γ production and promotes dendritic cell activation by upregulating B7 molecules. In infectious diseases, CD137 signaling significantly impacts the activation and cytokine production of γδ T cells. CD137 also plays an important role in the tumor microenvironment, with its expression on tumor vasculature and various tumor cells making it a potential target for immunotherapy.